The treatment trials include hyperthermia-based therapies, bladder-sparing chemoradiation therapies, and novel agents for advanced bladder cancer. The uproar began last week when The Cancer Letter , a Washington, D.C., newsletter, reported that Anil Potti had apparently lied about being a Rhodes scholar and made other unverifiable claims on . Phase: N/A Principal Investigator: Thomas Polascik Sponsor: Genomic Health, Myriad Genetics Contact: Denise Lech Phone: 919-681-7348 Reference Number: 00070017 Clinical Trials: N/A. Mission. 919.470.8600 . Participate in Clinical Trials/Knowledge of Clinical Trials African-American patients ranked their physi- There were no differences between groups (African- cian's advice lower (7.1) compared with white patients American patients vs. white patients and Duke Clinic (8.4) with regard to its influence on their decision to patients vs. QUADRA: A single-arm, multicenter phase 2 trial evaluating safety and efficacy of niraparib as fourth or later line of therapy. Duke restarted the clinical trials. Journal Article (Journal Article;Systematic Review) Cancer is a disease of aging and, as the world's population ages, the number of older persons with cancer is increasing and will make up a growing share of the oncology population in . methodology interests focus on oncology clinical trial design, survival analysis, surrogacy evaluation and missing data analysis, which led to publications on both statistical and clinical oncology journals, such as statistics in medicine and clinical cancer research. Research Approach and Overview The Polascik research group is dedicated to developing the clinical methodology for performing in-situ targeted therapy for early stage prostate cancers. Neuro-Oncology. Duke researchers use the modified virus to spur natural immune attack against tumors in animal studies Published January 30, 2020 | Updated January 30, 2020 DURHAM, N.C. -- A modified form of poliovirus, pioneered at Duke Cancer Institute as a therapy for glioblastoma brain tumors, appears in laboratory studies to also have applicability for pediatric brain tumors when used as We conduct clinical trials in the following areas: A cancer therapy co-invented by Duke engineers and Rice University has crossed a milestone in clinical trials, a major development in a decadeslong quest to develop a treatment that destroys tumors without the debilitating side effects of chemotherapy, invasive surgery and radiation. Select a research subject to learn about current trials in our division: Figured I'd give you an update from the Duke CHAMP clinical trial I was on. Contact the Duke Recruitment Innovation Center at MyResearchPartners@duke.edu or 919-681-5698 . Home Clinical Trials at Duke Clinical Trials Directory. Hormonal Therapies. DOCR is a consolidated group of research support professionals who are skilled in all aspects of clinical research, including study startup, database development, and project coordination. Duke Cancer Center North Durham. The Duke Division of Pulmonary, Allergy, and Critical Care Medicine offers patients access to new therapies through participation in carefully designed clinical trials. Kidney cancer research at Duke places an emphasis on translational programs that can have direct consequences on improving patient care and surgical therapy. We conduct innovative research to deliver on our mission to share knowledge that improves health around the world. "Our intent all along was to enable clinical trials at a place like Duke, which is at the forefront of both cancer treatment and research." This research was supported in part by Duke's Clinical and Translational Science Award, NIH grant number UL1TR001117. In October 2020, Duke University School of Medicine opened a clinical research center in the Durham community to address the urgent need for COVID-19 clinical research space. We have instituted safety measures throughout Duke Health hospitals and clinics to keep everyone safe and protected from possible exposure to COVID-19. During the trial, we paused the immuno therapies twice due to Gastrointestinal havoc (extensive puking and diarrhea). Dr. Call to Participate What is the Purpose of this Study? The study is divided into two periods: a screening period and a study dosing period. Precision Cancer Medicine and Investigational Therapeutics. The Preston Robert Tisch Brain Tumor Center Clinical Research Team conducts a variety of research efforts to support principal investigators. Duke Cancer Center. But in recent years, it has been resurrected as a potential treatment for deadly brain cancers. The goal of the Duke Liver Center is to prevent death from liver disease. Duke CHAMP trial results: Stable. Traditionally, randomized clinical trials for cancer therapies have considered time-to-event endpoints such as progression-free survival (PFS) and overall survival (OS) as the primary outcome measure in trial Clinical trials of hematopoietic growth factors, biological agents and targeted drug development. This is the only Duke facility entirely dedicated to clinical research, with a diverse, bilingual staff. The Clinical Trials Unit at Kilimanjaro Christian Medical Center has prepared numerous Standard Operating Procedures (SOPs) for clinical trials that meet NIH requirements. Using Polio to Cure Brain Cancer: Clinical Trials. Abstract IA18: North Carolina Central University and Duke Cancer Institute's collaborative cancer research and education program: Connecting cancer disparities translational research, clinical trials operations, and community engagement Conference Paper. 2021 Apr;7:495-505. doi: 10.1200/GO.20.00571. " Cancers (Basel) 13, no. Clinical Trials. Scotland Cancer Treatment Center and Duke are proud to offer a variety of trials to the greater Scotland community, such as treatment trials, quality-of-life trials, and registry trials. He has served as an associate editor for Journal of the National Cancer Institute, Statistics in Medicine, Statistics in Biosciences, Clinical Trials, and Biometrics. Beyer notes that the long and winding road has led them to exactly where they hoped to be. Published version (via Digital Object Identifier) Duke Authors . Alliance A151216 (Lung Cancer) - Clinical Trial. STOP CRC, which is exploring innovative approaches for increasing colon cancer screening rates among low-income and . During this . Older adult participation in cancer clinical trials: A systematic review of barriers and interventions. DOORS . Layout table for additonal information During Fiscal Year 2021, Duke had over 2,378 active clinical research studies, and 1018 of those were open to enrollment. " The Impact of Enzalutamide on the Prostate Cancer Patient Experience: A Summary Review of Health-Related Quality of Life across Pivotal Clinical Trials. While patients who enroll in clinical trials may feel like they are navigating uncharted territories, they are giving Duke Non-Alcoholic Fatty Liver Disease Research Program. This outcomes database should allow us to compile and analyze information regarding: The best surgical techniques and outcomes; Ways to minimize potential complications; Strategies to preserve kidney function after . 2021 May;161(2):496-501. doi: 10.1016/j.ygyno.2021.02.014. 4.) In addition, several dozen prominent biostatisticians and cancer researchers at Harvard, Princeton, Johns Hopkins and other academic institutions questioned the methodology behind the three clinical trials and urged a halt to the Duke studies — two on lung cancer and one on breast cancer — in a letter to the director of the National Cancer . Duke University has suspended three cancer clinical trials in response to allegations that a key researcher on the studies embellished his resumé. JCO Glob Oncol. Most people remember polio as the scourge that paralyzed millions of children until a vaccine was developed in the 1950s. Cancer Prevention and Control. 3.) Most of the issues addressed are also important for clinical trials in other settings. If you are found to be eligible, you will continue on to the study dosing period. A woman was referred to an obstetrician-gynecologist after she presented with postmenopausal bleeding during a routine examination. The team is comprised of research nurses, clinical trial coordinators, data managers and regulatory staff, and has experience in enrollment to Phase 1, Phase 2, Phase 3, Supportive Care and Quality of Life studies. Subjects on this portion of the study will be enrolled at the Duke Cancer institute and select external collaborating institutions. discuss ongoing clinical trials. The research trials conducted by our faculty include radiation therapy, radiation therapy combined with chemotherapy agents, devices, imaging studies, supportive care, quality of life and tissue/blood sampling research. Death is caused by cirrhosis and liver cancer. The Duke Department of Neurosurgery is actively involved in clinical research to improve treatment options for patients at Duke and around the world. In addition, we are investigating the pathological basis for focal therapy. DERIVe (Glioblastoma) - Clinical Trial What is the Purpose of this Study? National Institutes of Health Contributors . Drs. Two global studies of enzalutamide and apalutamide evaluated their safety and . Clinical trials may be designed to evaluate promising new products, pharmacologic agents (drugs or biologics), devices . The patient was referred to Duke for further evaluation and work-up. Research includes development of candidate selection, imaging, treatment schemes, and post-treatment surveillance. Duke University has settled the lawsuit filed by the families of eight cancer patients treated in clinical trials based on bogus science, a Duke spokesman said Saturday. Our clinical research is leading to expanded use of targeted therapies, new screening protocols, and better ways to reduce . Clinical trials hold the key to curing cancer and enhancing survival for our patients." Dr. Gaillard is currently at Johns Hopkins University, but also holds an adjunct position at Duke Cancer Institute. Findings on endometrial biopsy revealed grade 2 endometrial adenocarcinoma. Duke Cancer Institute has seven basic, clinical, and translational NCI-Designated Programs designed to address research opportunities impacting cancer care. Some trials may not be listed below. Tackling Diversity in Prostate Cancer Clinical Trials: A Report From the Diversity Working Group of the IRONMAN Registry. Laboratory studies are already underway in breast cancer models. Lung cancer/new treatment approaches. Please note that this is a partial list of clinical trials available at Duke. Questions? If you choose to join this study, during the screening period you will: - Have physical exams - Have blood draws - Have other tests done to assess your eligibility The screening period will last for about one month. Our team at The Preston Robert Tisch Brain Tumor Center understands the need to cross new thresholds when it comes to discovering the cure for brain cancer. What is the . Cancer in the elderly and supportive care. Clinical research is critical to our collective mission of reducing the burden of kidney cancer, and we're committed to designing better treatments and preventive approaches. white and African-American patients who were treated at the Duke Cancer Clinic were more willing to participate in a trial compared with their counterparts who were treated at DOORS clinics (47% vs . The Duke Cancer Center takes pride in bridging the gap between cancer care and research by unifying more than 300 researchers and physicians, along with 500 clinical staff members. Through our clinical research, we have consolidated an outcomes database for clinical renal tumors. DUCIMAS - Duke Cancer Institute Multidisciplinary Active Surveillance (DUCIMAS) Cohort Study. Duke Cancer Center Raleigh. During Fiscal Year 2021, Duke had over 2,378 active clinical research studies, and 1018 of those were open to enrollment. Duke Division of Medical Oncology researchers are working to extend and improve the life of cancer patients through prevention and treatment trials, many of which were initiated by Duke investigators. 16 Replies. DCRI projects are led by physician scientists whose grounding in patient care . Enrolling 463 patients with platinum-resistant or refractory ovarian cancer—more than 30 of whom were from Duke—the trial had a high response rate in women with BRCA mutations (31 percent . 2. to buy deodorant again, gained bone density and good muscle mass. The Duke Cancer Center Brain Tumor Clinic is part of the Preston Robert Tisch Brain Tumor Center, an institute leading the way in comprehensive care that combines research breakthroughs, clinical trials, and the newest therapies for brain cancer.Our clinic is staffed by specialists who provide consultations for people suspected of or diagnosed with metastatic cancer that has spread to the . 2011 Dec 14;12:261. doi: 10.1186/1745-6215-12-261. You may be eligible to participate in our clinical trials, which test new cancer therapies, and explore genomics, the study of genes, how they function, and their impact on health. The utility of Aspirin in Dukes C and High Risk Dukes B Colorectal cancer--the ASCOLT study: study protocol for a randomized controlled trial. Clinical Trials. One of the most common methods used to analyze these time-to-event endpoints is the Cox proportional hazard regression model. Utilizing an interim futility analysis of the OVAL study (VB-111-701/GOG 3018) for potential reduction of risk: A phase III, double blind, randomized controlled trial of ofranergene obadenovec (VB-111) and weekly paclitaxel in patients with platinum resistant ovarian cancer. The combination therapies have been front-line treatments for HER2-positive breast cancers, but the way they work has not been well understood. The lawsuit, filed Wednesday in a North Carolina court, comes 14 months after a scandal erupted at Duke that finally exposed the . Research Approach and Overview. Trials. Although most of these SOPs were developed for AIDS clinical trials, many . Duke Division of Medical Oncology researchers are working to extend and improve the life of cancer patients through prevention and treatment trials, many of which were initiated by Duke investigators. DOCR is a consolidated group of research support professionals who are skilled in all aspects of clinical research, including study startup, database development, and project coordination. Susan Halabi is a Professor of Biostatistics and Bioinformatics at Duke . Beyer notes that the long and winding road has led them to exactly where they hoped to be. [Walter Jacobs, audio recording: I'm recording this with your permission. Image. The Duke team is moving to expand its work and open a clinical trial for children with brain tumors, which is expected to begin enrollment before year's end. The KCRP Clinical Trial Award supports the rapid implementation of early-phase clinical trials (phase 0, phase 1, phase 1/2) with the potential to have a significant impact on the treatment or management of kidney cancer. High T clinical trial update from a data point. Duke University has suspended a cancer researcher for allegedly lying on his résumé, and now, independent scientists want to halt clinical trials based on his work until it can be properly reviewed. Image. The settlement ends . Through a better understanding of the causes of prostate cancer progression, Duke clinicians and researchers hope to develop strategies to individually tailor therapy or prevention based on a man's unique characteristics, Treating Endometrial Cancer. Full Text. Duke Cancer Center Cary Radiation Oncology. Secord and Gaillard continue to focus on treating patients with gynecologic malignancies and conducting translational research. Clinical Trials: N/A. Like Follow Watch Subscribe. Current clinical research trials are being conducted in relation to the following topics. 1. clinical trial designs and analysis of treatment effects for cancer therapies that may impact our understanding of investigational drugs. DGHI is pleased to share these documents with others who are working in resource-limited locations. A number of clinical trials are currently in progress for bladder cancer patients and range from studies of new diagnostic tests to novel treatment regimens for cancer. We are doing this study to research the genes of patients with lung cancer that has been or will be removed by surgery for a chance to get treatment in a clinical trial. Immuno-Oncology. 3. His research program spans the continuum from basic cancer research, to translational radiation biology, to clinical trials, such as SU2C . Medicine, Medical Oncology; Awarded By . Dr. Kelly Marcom, Director of the Breast Cancer Program, opened the clinical session, moderated by Dr. Oluwadamilola "Lola" Fayanju, who is the surgical lead for the IBC clinic, and pathologist Dr. Shannon McCall, with an overview of the Duke Breast Cancer Program, which was launched in 1981 and was the first If you choose to join this study, during the screening period you will: - Have physical exams - Have blood draws - Have other tests done to assess your eligibility The screening period will last for about one month. These efforts ensure our patients receive more personalized treatment options. The study is divided into two periods: a screening period and a study dosing period. Contact Contact Us 888-ASK-DUKE (888-275-3853) Our Locations Connect Connect With Us. As a review, I had 8 courses of Docetaxel before I started the CHAMP trial. The institute consists of more than 300 experts who conduct basic, clinical, translational, and population sciences research across 11 disease sites. Email address crawf006@mc.duke.edu. Researchers at Duke University ran a Phase I * trial by injecting a modified . Our clinical research is leading to expanded use of targeted therapies, new screening protocols, and better ways to reduce . Clinical Research. Forty-five percent of white patients, compared with 31% of African-American patients, were willing to participate in a clinical trial (P = 0.05). Clinical research is critical to our collective mission of reducing the burden of prostate cancer by designing better treatments and preventive approaches. Clinical Research. The Strategies and Opportunities to Stop Colon Cancer in Priority Populations (STOP CRC) study was recently featured on National Public Radio's Shots Blog, which is devoted to coverage and discussion of health and healthcare issues.. Public-domain image via Wikimedia Commons. Duke-UNC-Wash U Partnership for Early Phase Clinical Trials in Cancer Administered By . Chugach • 3 years ago. Perhaps our most advanced methods of scientific exploration come in the form of clinical trials. His research areas include Bayesian statistics, clinical trial design, precision medicine, and dynamic treatment regimes. You may find additional clinical trials at Duke by searching clinicaltrials.gov. For questions regarding cancer trials at Duke, please Contact Us. Campus mail 25177 Morris Bldg, Durham, NC 27710. HerbieP • 7 months ago. We are doing this study to understand whether the study vaccine, called pp65 CMV dendritic cells, can trigger your immune (protection) system to fight off the tumor cells in your brain. 919.684.2410 . Recent Clinical Trials. Contact Contact Us 888-ASK-DUKE (888-275-3853) Our Locations Duke Blood Cancer Center. And that's when Juliet and Walter Jacobs sat down for their first meeting with Dr. Potti. Traditionally, randomized clinical trials for cancer products have considered time-to-event endpoints such as progression-free survival and overall survival as the primary outcome measure in trial design. Our extensive research programs give our patients access to groundbreaking developments in patient care through carefully designed clinical trials. Gynecol Oncol. Approximately 17,800 Duke patients . Duke Prostate & Urologic Cancer Center is leading clinical trials which are improving the way we diagnose and treat prostate cancer. Back and ready for the next fight. "At Duke, our focus is on developing trials that are geared toward these patient populations, the specific types of molecular alterations that the metastasis may have, the side effects of treatments, and quality-of-life considerations that are very unique to this patient population." Now, with funding from the Duke CTSA through the Duke Translational Research Institute (DTRI) Collaborative Pilot Award, an interdisciplinary . 23 (November 23, 2021). Duke CHAMP clinical Trial Update. Clinical Trials. As a physician-scientist, he cares for bone and soft tissue sarcoma patients with radiation therapy in the Duke Cancer Institute. Radiographic progression-free survival (rPFS) is defined as the time (in months) from the date of randomization to the date of radiographic disease progression based on the central review assessment per the Prostate Cancer Clinical Trials Working Group 3 (PCWG3) criteria or death due to any cause. The Duke Clinical Research Institute, part of the Duke University School of Medicine, is the world's largest academic clinical research organization. 919.781.7070 . Cancer Risk, Detection and Interception. During this . Cancer Biology. I've had my first infusion of the two chemos cabazitaxel and carboplatin and two immuno-therapies. Phone (919) 681-9509. Our physicians work with pharmaceutical companies to design clinical trials that allow us to study all phases of prostate cancer and to focus on the following areas: Approximately 17,800 Duke patients . David Kirsch, MD, PhD, is the Barbara Levine University Professor at Duke. Both cirrhosis and liver cancer develop when an injured liver is not able to repair, or regenerate, properly. DCI's leadership team oversees all aspects of cancer care, cancer-related research, and cancer-related education across Duke University and the Duke University Health System. 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